A tyrosine kinase Src; regulator of bone homeostasis

Author Info

Shoichiro Kokabu Takuma Matsubara Tatsuki Yaginuma

Corresponding Author

Takuma Matsubara
Division of Molecular Signaling and Biochemistry, Kyushu Dental University, 2-6-1, Manazuru, Kitakyushu, Fukuoka, 8038580, Japan

A B S T R A C T

The balance of bone formation by osteoblasts and bone resorption by osteoclasts is important for bone homeostasis. Pathologic high activity of osteoclasts and repression of bone osteoblastic bone formation result in bone metabolic diseases such as periodontal disease. To understand the mechanism of osteoblast and osteoclast function leads to establishment of therapy for bone metabolic disease. A tyrosine kinase Src deficient mice shows osteopetrosis because of defect bone resorbing activity and acceleration bone formation. This indicates Src is a key molecule to regulate bone resorption and bone formation. We discuss about the role of Src in osteoclast and osteoblast and entire bone metabolism.

Article Info

Article Type

Research Article

Publication history

Received: Wed 30, Jan 2019
Accepted: Fri 15, Feb 2019
Published: Thu 28, Feb 2019

Copyright

© 2023 Takuma Matsubara. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.DOBCR.2019.01.003