Directionality of Chemical Reaction and Spontaneity of Biological Process in the Context of Entropy

Directionality of Chemical Reaction and Spontaneity of Biological Process in the Context of Entropy

Review Data

Q: Is the topic relevant to the journal's area of interest? Is it contemporary and interesting for researchers?

A: Good


Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good



Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good



Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good


Tools and Methods

Q: Are the methods the author uses adequate and well used?

A: Good


Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them coherent?

A: Good


Comments: The Discussion elaborates on the thermodynamic property entropy in chemical reactions. Moving ahead, the authors discussed how the errors in information transfer from DNA to RNA significantly impair gene function and lead to misfolded and poorly functioning proteins.  The Discussion further suggests that entropy represents the negative and passive side of the matter, while potential energy shows a positive and active side. In conclusion, the authors put forward the importance of predicting the directionality of reactions and how entropy plays a significant role in predicting the direction and spontaneity of the reaction.



Q: Does the author utilize relevant literature?

A: Good


Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good



Q: Is the length of the paper adequate for the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good


Figures & Tables

Q: Does the author use them suitably? Are legends and notations clear?

A: Good


Writing style

Q: Is it clear and understandable?

A: Good


Further comments on the paper

Comments: The manuscript illustrates the directionality of chemical reaction and spontaneity of biological process with respect to entropy. The study further discussed the entropy in chemical reactions, living systems. The authors also highlighted the significance of macromolecules in terms of potential and entropy. 


Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions or clarifications you can write to the journal.

Science Repository Team



Author Info

Corresponding Author
Jawad Alzeer
Swiss Scientific Society for Developing Countries, Zurich, Switzerland

Article Info

Article Type
Review of the Literature
Publication history
Received: Thu 29, Sep 2022
Accepted: Mon 17, Oct 2022
Published: Mon 31, Oct 2022
© 2023 Jawad Alzeer. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.RGM.2022.02.06