Microfractured Adipose Tissue Graft for the Advanced Treatment of Non-Healing Cutaneous Fistulas

Microfractured Adipose Tissue Graft for the Advanced Treatment of Non-Healing Cutaneous Fistulas

Review Data

Q: Is the topic relevant to the journal's area of interest? Is it contemporary and interesting for researchers?

A: Good


Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good



Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good



Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good


Tools and Methods

Q: Are the methods the author uses adequate and well used?

A: Very good


Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them coherent?

A: Good



The study provides significant information about the importance of adipose tissue as the ideal source for the recruitment of mesenchymal stem cells both because it is easily accessible, because it is generally present in abundance and because it is extremely rich in pericytes that are progenitors of MSCs (mesenchymal stem cells). The research paper is very well supported with briefly explained figures. The Discussion puts forth the rationale for taking up the study, effectively describes the relevant literature and enlists the implications of the findings from the present study in that context. The Conclusion section aptly summarizes from the results of the study that the treatment of non-healing cutaneous fistulas by MFAT (Micro Fractured Adipose Tissue) transplantation allows in many cases an immediate repair or an acceleration of the repair process.



Q: Does the author utilize relevant literature?

A: Very good


Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good



Q: Is the length of the paper adequate for the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good


Figures & Tables

Q: Does the author use them suitably? Are legends and notations clear?

A: Very good


Writing style

Q: Is it clear and understandable?

A: Very good


Further comments on the paper

Comments: This study aims to describe in detail the implemented method of the used device accompanied by the document with adequate photographic documentation. This paper reports the efficacy of MFAT (Micro Fractured Adipose Tissue) in the treatment of difficult-to-heal skin fistulas of different etiologies.


Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions or clarifications you can write to the journal.

Science Repository Team


Author Info

Corresponding Author
Marco De Monti
EOC - Beata Vergine Regional Hospital, Department of Surgery, Mendrisio, Switzerland

Article Info

Article Type
Research Article
Publication history
Received: Thu 22, Sep 2022
Accepted: Wed 12, Oct 2022
Published: Fri 28, Oct 2022
© 2023 Marco De Monti. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.RGM.2022.02.05