Remdesivir for the Treatment of Severe SARS-CoV-2 (COVID-19): A Systematic Review and Meta-Analysis

Remdesivir for the Treatment of Severe SARS-CoV-2 (COVID-19): A Systematic Review and Meta-Analysis

Review Data

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good



Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good



Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good


Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good


Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good



The Discussion thoroughly covers the implications of the findings from this meta-analysis and offers an insightful comparison with the other relevant ones in the literature. It concludes that remdesivir is effective in the treatment of severe COVID-19 patients of younger age and without the need of invasive ventilation, it reduces time for clinical improvement and reduces mortality irrespective of ethnicity; however, clinicians must be vigilant for possible severe adverse events.



Q: Does the author utilize relevant literature?

A: Very good


Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good



Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Very good


Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good; Table 1 is not mentioned in the text.


Writing style

Q: Is it clear and understandable?

A: Very good; However, a few minor issues were noted –

·       “Angiotensin” was misspelled.

·       “Decrease of” must be replaced with “decreasing by” in the 2nd sentence of the 4th paragraph of the Methods.

·       Some prepositions were incorrectly used, e.g., after “Subgroup analysis” in the 1st sentence of the 5th paragraph of Results, after “indicator” in the 1st sentence of the 8th paragraph of Discussion, and so on.

·       There were some incorrect punctuations, missed articles (i.e., “a”, “an”, or “the”), and so on.


Further comments on the paper

Comments: This is an up-to-date systematic review and meta-analysis of 6 relevant studies on the effectiveness of remdesivir, the RNA-dependent RNA polymerase inhibitor antiviral, in the treatment of SARS-CoV-2 in the literature. The dearth of adequate data on this subject and the fact that we still have a long way to get to the other side of the pandemic, with no standard treatment currently and selective mass vaccination just starting off, calls for rapid publication of the manuscript.


Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions and clarifications you can write to the journal.

Science Repository Team


Author Info

Corresponding Author
Zhipeng Yan
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong

Article Info

Article Type
Review Article
Publication history
Received: Sat 21, Nov 2020
Accepted: Sat 05, Dec 2020
Published: Wed 23, Dec 2020
© 2023 Zhipeng Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.RGM.2020.04.01