Impact of Target-Controlled Infusion (TCI) of Propofol on State- and Response-Entropy and Sedation Depth During Flexible Bronchoscopy

Impact of Target-Controlled Infusion (TCI) of Propofol on State- and Response-Entropy and Sedation Depth During Flexible Bronchoscopy

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for


A: Good


Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good



Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good



Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good


Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good


Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good


Comments: The Discussion provides a brief account of the observational study in understanding of the impact of Target Controlled Infusion (TCI) compared to bolus administration of propofol on sedation depth during flexible bronchoscopy providing relevant literature. Additionally, author also discusses the advantages and limitations of TCI. Lastly, the study provided a concludes that TCI of propofol provides a deep and steady level of sedation and is particularly beneficial for the requirements of time-consuming procedures or interventions during flexible bronchoscopy.



Q: Does the author utilize relevant literature?

A: Good


Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good



Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good


Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very Good


Writing style

Q: Is it clear and understandable?

A: Good

Comments: Certain errors are found in the manuscript which are as follows:

·       Under Introduction, 1st paragraph, 2nd sentence, “Still, the examination can cause discomfort …  harming reactions” should be “Still, the examination can cause discomfort …harmful reactions”.

·       In Patients and Methods, 6th paragraph, 3rd sentence, “All patients were breathing spontaneously a mixture of air and supplemental oxygen (2-6L/min)” should be reframed as “All patients were breathing a mixture of air and supplemental oxygen (2-6L/min) spontaneously”.


Further comments on the paper

Comments: The manuscript highlights the potential benefits of Target Controlled Infusion (TCI) of propofol on sedation depth during Flexible Bronchoscopy. The research describes the cohort study of patients following the research procedure and its limitations. Further, the results put forth the outcome of the study representing data in the tabular form.


Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions and clarifications you can write to the journal.

Science Repository Team 


Author Info

Corresponding Author
Cornelius Husemann
Department of Anesthesiology and Intensive Care, Technical University of Munich, School of Medicine, Munich, Germany

Article Info

Article Type
Research Article
Publication history
Received: Mon 10, Jan 2022
Accepted: Wed 26, Jan 2022
Published: Wed 16, Feb 2022
© 2023 Cornelius Husemann. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.ACR.2022.01.01