Decreased Expression of Metastasis Suppressor 1 Correlates with Poor Prognosis of Patients with Rectal Adenocarcinoma

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

The study is well designed and executed. The Methods and Results are adequately described. The Discussion offers a thorough and detailed analysis of the findings of the present study taking all the relevant literature into account. The experiments performed are really convincing and the observations are properly explained and discussed in the Discussion section. The present study not only shows that the reduced expression level of MTSS1 is associated with the tumor stages, but also reveals that the lower protein expression levels of MTSS1 are significantly correlated with the shorter progression-free survival (PFS) time and poorer overall survival (OS) of patients with rectal adenocarcinoma. It Concludes from the results of the study that MTSS1 might serve as an independent prognostic factor for patients with rectal adenocarcinoma.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Very good

Further comments on the paper

Comments: This study aims to explore the MTSS1 expression in rectal adenocarcinoma in the tropical area of China and its correlation with prognosis. The study holds importance as identification of novel biomarkers of rectal adenocarcinoma will be of great importance in promoting the survival rate of patients with rectal adenocarcinoma. The present study shows that both mRNA and protein levels of MTSS1 are down-regulated in rectal adenocarcinoma cells and tissues, and that this downregulation is significantly correlated with the advanced stages of this disease. The patients included in this study being solely from the Chinese population comes out as one of the limitations of this study.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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