Co-Occurrence of Multiple Sclerosis & Ovarian Cancer: A Case Report and Literature Review

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Excellent

Comments: The case description is adequate. The Discussion section thoroughly analyses the association between ovarian cancer and autoimmune disease by discussing adequate literature relevant to the study. The Conclusion section emphasizes the importance of early diagnosis and timely surgical and/or chemotherapeutic treatment in order to treat ovarian cancer in patients diagnosed with multiple sclerosis.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Insufficient

Writing style

Q: Is it clear and understandable?

A: Good

Comments:

·       The 2^nd sentence of the 6^th paragraph of the Discussion should be rephrased as “When she relapsed into MS two years ago, she was changed to corticoids maintenance therapy after relief by corticoids pulse therapy.”

·       In the 6^th sentence of the 7^th paragraph of the Discussion, the word “partially” should be replaced with “partial” and “sensitivity” should be replaced with “sensitive”.

·       The word “laquinimod” is misspelled in the text section of the article.

Further comments on the paper

Comments: This case report presents a case of a 58-year-old female patient, diagnosed with multiple sclerosis (MS) and early epithelial ovarian carcinoma. It focuses on the importance of surgical interventions such as hysterectomy, bilateral salpingo-oophorectomy, omentectomy and pelvic and para-aortic lymph node dissection which lead to better outcomes with no presence of residual cancer foci. This study emphasizes the association between autoimmune diseases and the development of cancer which may be due to the long-term complication of immunomodulatory and immunosuppressive therapy and lack of effective screening test strategies. It states that alarmingly vague presenting symptoms of these cases make the diagnosis challenging. Therefore, A high index of suspicion is required to facilitate early diagnosis and management of such co-occurrence of MS and ovarian cancer.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions and clarifications you can write to the journal.

Thanks,
Science Repository Team