Effect of Electrospinning Parameters on the Fiber Diameter and Morphology of PLGA Nanofibers

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for researchers?

A: Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Excellent

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments: The Discussion section, with the help of adequate relevant literature, determines the appropriate electrospinning parameters such as applied voltage, flow rate, spinneret-collector distance (S-C distance) and polymer solution concentration for preparation of poly lactic-co-glycolic acid (PLGA) fibrous membrane for guided tissue regeneration/guided bone regeneration (GTR/GBR) applications and analyses the effect of the parameters on the mean fiber diameter of the electrospun PLGA nanofibers. The Conclusion states that there is a significant variation in the mean fiber diameter with altering solution concentration and the electrospinning parameters such as applied voltage, polymer solution flow rate and S-C distance, thus rejecting the null hypothesis. It also identifies the appropriate measures of the parameters for the production of PLGA nanofibers to be used in the GTR/GBR membrane fabrication.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Excellent

Writing style

Q: Is it clear and understandable?

A: Very good

Further comments on the paper

Comments: This study evaluates the effect of electrospinning parameters and polymer solution concentration on the mean fiber diameter of the electrospun poly lactic-co-glycolic acid (PLGA) nanofibers and determines the appropriate electrospinning parameters such as applied voltage, flow rate, spinneret-collector distance (S-C distance) and polymer solution concentration for the production of PLGA nanofibers to be used in the guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane fabrication. PLGA is a FDA-approved synthetic biodegradable polymer which has an excellent potential in a wide range of biomedical applications due to its unique properties. The findings of this study indicate that there is a significant variation in the mean fiber diameter with altering applied voltage, solution concentration, flow rate and S-C distance and thus, rejecting the null hypothesis. Thus, this study identifies the appropriate measures of the parameters and demonstrates that electrospinning parameters and solution concentration have a significant influence on the mean fiber diameter of electrospun PLGA nanofibers. Further studies are required to correlate the effect of mechanical properties and physical properties with mean fiber diameters and to determine the applicability of these nanofibers in various biomedical applications.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team