Hypotensive Effect Induced by Mandibular Extension in Aged, Hypertensive Humans and Rats

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Excellent

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Excellent

Comments: The Discussion section, with the help of adequate relevant literature, demonstrates that submaximal mouth opening by mandibular extension (ME) induces a prolonged reduction in blood pressure, particularly in systolic pressure, not only in normotensive but even more in hypertensive subjects. In Conclusion, this study states that passive ME may be used as non-pharmacological aid in the treatment of moderate to mild arterial hypertension.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This study provides the first evidence that mandibular extension (ME) has a significant role in inducing hypotensive effect when applied to rat and human subjects with high blood pressure, making their arterial blood pressure decrease toward normal values for at least two hours. It states that a passive sub-maximal opening of the mouth causes a significant reduction in arterial blood pressure. The findings suggest a relation between baseline blood pressure and hypotensive response so that the effects of ME appear greater in the hypertensive condition. This study is limited due to small sample size.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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