Systematic investigation of a new nanoscale bioactive glass on wound healing in vivo in comparison with the clinically applied 45S5 Bioglass
Corresponding AuthorZhongru Gou
Zhejiang-California International NanoSystems Institute, Zhejiang University, Hangzhou, 310058, China
A B S T R A C T
Aim: Recently, bioactive glass (BG)-based inorganic biomaterials which differ from polymer wound dressings have become a promising candidate favorable for improving acute wound healing and even some chronic, non-healing wound repair. We developed a new sol–gel-derived BG (Sol-nBG) nanomaterial and evaluated its biological efficacy on wound healing based on the antibacterial and wound-healing accelerating potentials of the specific trace elements in the chemical composition of Sol-nBG. Materials and methods: The sol-nBG powder was prepared by a facile sol–gel route which readily resulted in nanoscale particles after undergoing a low-heat calcination process. The amorphous nature of the SolnBG powder was confirmed by X-ray diffraction analysis, and the biologically-active ions such as calcium, silicon, zinc, and boron could be rapidly released in Tris buffer, similar to the orthopedically and dentally available 45S5 Bioglass@ (45S5 BG). In particular, the Sol-nBG and 45S5 BG particles were well tolerated by the surrounding host wound tissue without causing any chronic inflammation, and appreciably enhanced the wound healing of a deep second-degree scald. Results and Conclusions: The results showed that the Sol-nBG significantly promoted wound healing with increased epidermal and dermal regeneration and collagen deposition in comparison with the 45S5 BG or control treatment. Therefore, it is reasonable to consider that the new Sol-nBG facilitates wound treatment and is a promising candidate for wound healing in future.
Article TypeResearch Article
Publication historyReceived: Tue 20, Mar 2018
Accepted: Thu 05, Apr 2018
Published: Tue 10, Apr 2018
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