Identification of BAP1-associated MicroRNAs and Implications in Cancer Development

Identification of BAP1-associated MicroRNAs and Implications in Cancer Development

Author Info

Corresponding Author
Tikam Chand
Genome and Computational Biology Lab, Department of Biotechnology, Mohanlal Sukhadia University, Udaipur-313001, Rajasthan, India

A B S T R A C T

Having role in gene regulation and silencing, miRNAs have been implicated in development and progression of a number of diseases, including cancer. Herein, I present potential miRNAs associated with BAP1 gene identified using in-silico tools such as TargetScan and Exiqon miRNA Target Prediction. I identified fifteen highly conserved miRNA (hsa-miR-423-5p, hsa-miR-3184-5p, hsa-miR-4319, hsa-miR125b-5p, hsa-miR-125a-5p, hsa-miR-6893-3p, hsa-miR-200b-3p, hsa-miR-200c-3p, hsa-miR-505-3p.1, hsa-miR-429, hsa-miR-370-3p, hsa-miR-125a-5p, hsa-miR-141-3p, hsa-miR-200a-3p, and hsa-miR-429) associated with BAP1 gene. We also predicted the differential regulation of these twelve miRNAs in different cancer types.

Article Info

Article Type
Research Article
Publication history
Received: Sun 25, Aug 2019
Accepted: Tue 08, Oct 2019
Published: Sat 09, Nov 2019
Copyright
© 2021 Tikam Chand. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository. All rights reserved.
DOI: 10.31487/j.IJCST.2019.01.01