Metabolomics of Rat Brain After Treatment with Phenelzine: High-Resolution Mass Spectrometric Demonstration of Increased Brain Levels of N-Acetyl Amino Acids
Metabolomics of Rat Brain After Treatment with Phenelzine: High-Resolution Mass Spectrometric Demonstration of Increased Brain Levels of N-Acetyl Amino Acids
Review Data
Significance of the Study: The study undertook mass spectrometric metabolomics analysis of rat cortical brain after intraperitoneal dosing with phenelzine or β-phenylethylidenehydrazine which showed elevated levels of N-acetyl amino acids in either of the treatments.
Fit for Journal: The manuscript is highly suited for the scope of the journal Neurology and Neurobiology.
The mass spectrometric analyses are aptly supported by the data. The Discussion explains all the necessary and relevant findings with regard to the drug inhibiting deacylases by β-phenylethylidenehydrazine.
The manuscript is mostly well-written except a few minor errors (already corrected in the galley proof), which are listed below –
§ In the 2nd sentence of 2nd paragraph of Discussion “amidohydolase” should be replaced with “amidohydrolase”.
§ For the sake of consistency, “nonspecific” in 1st sentence of Introduction should be written as “non-specific”.
§ Commas and articles, e.g., “the” were missing in several places throughout the text.
§ In the last sentence of Background in Abstract, “remain” should be replaced with “remains” and in the 1st sentence of Methods in abstract, “an” should be replaced with “and”.
Paul L. Wood
John E. Cebak
Glen B. Baker
Author Info
Corresponding Author
Paul L. Wood
Metabolomics Unit, College of Veterinary Medicine, Lincoln Memorial University, Tennessee, USA
Article Info
Article Type
Research Article
Publication history
Received: Sat 20, Jun 2020
Accepted: Tue 07, Jul 2020
Published: Fri 24, Jul 2020
Copyright
© 2023 Paul L. Wood. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.NNB.2020.03.03