Pulmonary Thrombosis in Acute Respiratory Distress Syndrome: Theory, Evidence, and Clinical Relevance to Resource-Limited Settings

Pulmonary Thrombosis in Acute Respiratory Distress Syndrome: Theory, Evidence, and Clinical Relevance to Resource-Limited Settings

Review Data

Q: Is the topic relevant to the journal's area of interest? Is it contemporary and interesting for


A: Very good


Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent



Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good



Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good


Tools and Methods

Q: Are the methods the author uses adequate and well used?

A: Good


Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them coherent?

A: Very good



This review article synthesizes the current treatment options of pulmonary thrombosis in acute respiratory distress syndrome and proposes why in resource-limited settings screening limitations will affect early intervention. The review is well supported with briefly explained figure and tables. Based on the data obtained from relevant literature, the study concludes that there is strong link between thrombosis and acute respiratory distress syndrome (ARDS) due to the dual activation of the two pathways involved. The review aptly recommends focus to be placed on the prevention, early recognition, and treatment of pulmonary thrombosis as part of endotheliopathy-associated vascular microthrombotic disease.



Q: Does the author utilize relevant literature?

A: Very good


Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good



Q: Is the paper's length adequate to the topic's significance? Do you suggest shortening the paper without losing its value?

A: Good


Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good


Writing style

Q: Is it clear and understandable?

A: Very good


Further comments on the paper

Comments: The aim of this review article is to specifically highlight the pathophysiology of acute respiratory distress syndrome (ARDS) and how it links to pulmonary thrombosis. This study holds significance as pulmonary thrombosis is a serious issue and a topic highly relevant given the current coronavirus pandemic situation which makes this link furthermore critical. This article adequately reviews the current treatment options, underlining that potentially life-saving thrombosis-screening procedures could be lacking in resource-limited settings.


Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions or clarifications you can write to the journal.

Science Repository Team



Author Info

Corresponding Author
Nicole Greeff
Department of Anaesthesiology and Critical Care, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa

Article Info

Article Type
Review Article
Publication history
Received: Fri 16, Sep 2022
Accepted: Fri 30, Sep 2022
Published: Mon 17, Oct 2022
© 2023 Nicole Greeff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.ACR.2022.03.04