Safety and efficacy of bone marrow mononuclear cell transplantation in the treatment of decompensated liver cirrhosis

Safety and efficacy of bone marrow mononuclear cell transplantation in the treatment of decompensated liver cirrhosis

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Corresponding Author
Yangjing Gao
Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China

A B S T R A C T

Aims: To evaluate the safety and efficacy of autologous bone marrow mononuclear cells (BM-MNCs) in the treatment of patients with decompensated liver cirrhosis. Methods: We randomly assigned 34 patients to control (18 cases) and BM-MNCs (16 cases) groups. All patients in the BM-MNCs group received granulocyte colony-stimulating factor for 3 days and were then infused with BM-MNCs. We then tested liver function, blood coagulation parameters, Karnofsky performance status (KPS), and the levels of procollagen IIIN peptide and hyaluronic acid. Results: Generally, the symptoms of patients in the BM-MNCs group improved significantly compared to controls. Six months after transplantation, total bilirubin level was 14.94±7.20μmol/L vs 24.50±15.34μmol/L (p=0.045), albumin level was 40.65±4.94g/L vs 34.78±4.92g/L (p=0.000), and prothrombin time was 10.86±1.18s vs 13.49±1.80s (p=0.002), respectively. KPS significantly improved when measured one month and six months after BM-MNCs therapy and showed obvious differences compared to controls. Changes in Child-Pugh score were also statistically significant when measured six months after therapy (p=0.001). Mean pretreatment serum baseline levels of procollagen IIIN peptide and hyaluronic acid were significantly lower than those measured one month after therapy (both p<0.05). Conclusions: Autologous transplantation of BM-MNCs is safe and effective for patients with decompensated liver cirrhosis and leads to improvements in liver function, hepatic Child-Pugh score and KPS.

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Article Type
Research Article
Publication history
Received: Sun 20, May 2018
Accepted: Wed 30, May 2018
Published: Mon 11, Jun 2018
Copyright
© 2019 Yangjing Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository. All rights reserved.
DOI: 10.31487/j.RGM.2018.02.002