Chemical and antifungal analysis of essential oils and phytochemicals against Candida albicans and Candida tropicalis

Chemical and antifungal analysis of essential oils and phytochemicals against Candida albicans and Candida tropicalis

Author Info

Corresponding Author
Ricardo Castro
Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil

A B S T R A C T

The aim of this study was to evaluate the chemical composition and antifungal activity of four essential oils (EO) and four phytochemicals against Candida albicans and Candida tropicalis. The chemical analysis of EO was carried out using a gas chromatograph coupled with a mass spectrometer. The antifungal evaluation was determined by means of the disc-diffusion in agar technique. The major components found were: eucalyptol (41.06%) and limonene (28.08%) in the EO of Cinnamomum camphora, geranial (51.17%) and neral (36.40%) in the EO of Melissa officinalis, (E)-anethole (77.14%) in the EO of Ocinum basilicum and citronellal (37.75%), citronellol (14.27%), citronellal (37.75%) and geraniol (18.84%) in the EO of Cymbopogon nardus. Against C. albicans and C. tropicalis strains, essential oils and phytochemicals produced, respectively, the following growth inhibition halos: C. camphora (11 mm; 14 mm), M. officinalis (32 mm; 30 mm), O. basilicum (32 mm; 30 mm), C. nardus (15 mm; 30 mm), alpha pinene (35 mm; 30 mm), citral (32 mm; 25 mm), citronellal (30 mm; 30 mm) and carvacrol (30 mm; 30 mm). Monoterpenes constitute the majority of the chemical components of essential oils tested. Phytochemicals have antifungal activity, inhibiting the growth of C. albicans and C. tropicalis.

Article Info

Article Type
Research Article
Publication history
Received: Mon 21, Jan 2019
Accepted: Mon 11, Mar 2019
Published: Fri 29, Mar 2019
Copyright
© 2021 Ricardo Castro. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository. All rights reserved.
DOI: 10.31487/j.CMR.2018.01.005