Regenerative and Endoscopic Treatment of Complex Recurrent Fistula in Ano: When Technology Supports Clinical Treatment

Regenerative and Endoscopic Treatment of Complex Recurrent Fistula in Ano: When Technology Supports Clinical Treatment

Review Data


Q: Is the topic relevant to the journal's area of interest? Is it contemporary and interesting for researchers?

A: Very good


Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent



Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good



Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good


Tools and Methods

Q: Are the methods the author uses adequate and well used?

A: Very good


Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good



The study is well designed and executed. The Methods and Results are adequately described. It is well supported with briefly explained table and figures. The Discussion offers a thorough and detailed analysis of the findings of the present study taking all the relevant literature into account. The study Discusses MFAT injections to be more effective in promoting tissue regeneration than simply “filling” the fistula tract. The Results are clearly explained and aptly supported by data. Based on the results obtained, the study aptly Concludes that the combination of video-assisted anal fistula treatment and injection of human autologous microfractured adipose tissue may be a valid, safe and feasible therapeutic option.



Q: Does the author utilize relevant literature?

A: Good


Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good



Q: Is the paper's length adequate to the topic's significance? Do you suggest shortening the paper without losing its value?

A: Good


Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good


Writing style

Q: Is it clear and understandable?

A: Very good


Further comments on the paper

Comments: This study proposes a combined approach of Video-Assisted Anal Fistula Treatment (VAAFT) plus Microfractured Adipose Tissue Graft (MFAT) in order to treat recurrent and complex fistula in ano. This study holds significance as recurrent anal fistulas present a challenge to surgeons due to the high risk of post-operative incontinence caused by repeated surgery. It consists of three cases treated with a combination of VAAFT and microfractured adipose tissue grafts. The small sample size comes out as one of the limitations of this study.


Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions or clarifications you can write to the journal.

Science Repository Team



Author Info

Corresponding Author
Marco De Monti
EOC - Beata Vergine Regional Hospital, Department of Surgery, Mendrisio, Switzerland

Article Info

Article Type
Research Article
Publication history
Received: Tue 06, Sep 2022
Accepted: Tue 20, Sep 2022
Published: Fri 07, Oct 2022
© 2023 Marco De Monti. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.RGM.2022.02.03