Hematopoietic Stem Cell Transplantation in Juvenile Myelomonocytic Leukemia: A Case Report and Literature Review

Review Data

Q: Is the topic relevant to the journal's area of interest? Is it contemporary and interesting for researchers?

A: Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are the methods the author uses adequate and well-used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments: The Discussion gives an overview of the origin and appearance of JMML among patients. It also illustrates the diagnostic criteria of the patients discussing the probable clinical symptoms. The authors also highlighted the fatal side of the JMML in children who do not receive transplantation providing relevant literature. Further, the Discussion highlights the complete management and treatment procedure of the disease. In Conclusion, the authors suggested that Allo-HSCT is the only modality to achieve a cure in JMML patients and Azacytidine is a promising agent in recent clinical trials to achieve hematological and molecular responses.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the paper's length adequate to the topic's significance? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: The manuscript presents a case report of a 2-year-old male child, illustrating hematopoietic stem cell transplantation in Juvenile myelomonocytic leukemia (JMML). The report describes the overview of the diagnosis, treatment and prognosis of the disease.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions or clarifications you can write to the journal.

Thanks,
Science Repository Team