Autologous Adipose-Derived Stem Cells, Platelet-Rich Plasma, and Fibrin Enhance Healing of Mandibular Bone Defects in Swine
Purpose and Significance of Study: This study provides the first evidence that the addition of both platelet-rich plasma and fibrin scaffolds to autologous ASCs from liposuction improves bone healing of critical-size defects in the craniofacial skeleton. The results also suggest that the addition of autologous blood products, either 20% platelet-rich plasma or fibrin scaffolds derived from whole blood supplemented with calcium phosphate, to adipose-derived stem cells derived from lipoaspirate, may be advantageous due to improved bone formation without requiring harvesting of patient bone. Thus, it shows potential for the improvement in cell therapies towards an autologous bone tissue construct for craniofacial bone repair.
Fit with Scope of Journal: The manuscript is of very high interest for the journal International Journal of Regenerative Medicine.
The discussion aptly elaborates on the findings, the possible causes behind them with respect to the different techniques employed, and the future implications.
o The manuscript is well-written. It contains a few very minor errors (already corrected in the galley proof), which are listed below –
· Omission of articles, e.g., “the” before “therapeutic” in the 1st sentence of the Abstract, before “addition” in the last sentence of the Abstract, and so on.
· Omission of “,”, e.g., after “specifically” in the 4th sentence of the 1st paragraph of the Introduction, after “construct” in the last sentence of the 2nd paragraph of the Introduction, and so on.
· “Grayscale” must be written as a single word.
Matthew B. Wheeler
Department of Animal Sciences, University of Illinois, Urbana-Champaign, Urbana, Illinois, USA
Received: Wed 27, May 2020
Accepted: Wed 10, Jun 2020
Published: Thu 18, Jun 2020
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