Pyrroloquinoline Quinone Enhances Cognition of Neuroinflammatory Alzheimer’s Disease Mouse Model via Mitochondrial Biogenesis Regulation

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Very good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Excellent

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

Comments:

The study is well designed and executed. The Introduction lays down the basics for taking up the present study. The Methods and Results are adequately described. The Discussion offers a thorough and detailed analysis of the findings of the present study taking all the relevant literature into account. The study is well supported with briefly explained figures. Finally, the study aptly Concludes by demonstrating the ability of pyrroloquinoline quinone (PQQ) to improve memory in neuroinflammatory Alzheimer’s Disease (AD) model through enhancement of mitochondrial biogenesis in the brain, and that improving mitochondrial biogenesis seems to represent another potential mechanistic approach for treatment of AD. The Conclusion also suggests to measure mitochondrial marker proteins and indicate the mitochondrial content in brain tissue to interpret the overall effect of PQQ on mitochondrial count.

Literature

Q: Does the author utilize relevant literature?

A: Very good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: This study aims to test the cognitive enhancement effect of pyrroloquinoline quinone (PQQ) in a neuroinflammatory mouse model mimicking Alzheimer’s Disease (AD), and whether PQQ is able to activate mitochondrial biogenesis in brains of the AD mouse model. The study holds significance as it is the first study to confirm cognitive enhancement effects of PQQ in a neuroinflammatory mouse model mimicking AD. The results showed and confirmed the pro-cognitive properties of PQQ on the neuroinflammatory mouse model based upon several performed cognitive tests. The study suggests that PQQ could retain a normal level of mitochondrial biogenesis in brain tissue after inducing neuroinflammation via lipopolysaccharide (LPS).

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team