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American Journal of Medicinal Chemistry (ISSN 2733-2519)

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In Press Volume 2, Issue 1

We are currently preparing the issue. Will be updated soon.

Editor-in-chief

Will be updated soon

Editorial board

Yaniv Lavon

Professional Manager and Researcher

Department of Animals Science

The Hebrew University of Jerusalem

Israel

About Me

Teaching assistant in the Faculty of Agriculture, Department of Animal Science (2003-2011) in the following courses: Biology of Lactation Comparative Reproductive Biology Dairy Cattle Management Bioclimatology of Domestic Animals Ruminants diseases AWARDS AND GRANTS Recipient of a scholarship from the Israel Cattle Breeders’ Association in 2006.  Recipient of a scholarship from the Israel Cattle Breeders’ Association in 2008.   Recipient of the "Laper" scholarship in 2007. Recipient of the "Whole Organism" scholarship in 2008, donated by the Ministry of Agriculture.

Jun Xu

Professor, Director and Founder of Research Center for Drug Discovery, Sun Yat-Sen University

Adjunct Professor of University of Pittsburgh (USA) and RMIT University (Australia)

Fellow of Royal Society of Chemistry

Guangzhou, China

About Me

I became Professor of Medicinal Chemistry and CADD, and the Director and Founding Professor of the Research Center for Drug Discovery (RCDD) and the HPC Center for Life Sciences (HPCCLS) at Sun Yat-Sen University (SYSU) in Guangzhou, China in 2009. Prior to joining SYSU, I worked in the pharmaceutical industry, practicing chemoinformatics and computer-aided drug design (CADD) for over 25 years. I was a director & Fellow of CADD at DPI/Biofocus, a principal scientist managing the computational chemistry and chemoinformatics group at Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI). Before joining BIPI, I held an R&D director position at BIO-RAD Sadtler Division and was a senior staff scientist developing drug discovery related technology at both OMG (now merged with Accelrys) and Tripos. RCDD consists of the laboratories of drug design methodology, structure biology, phytochemistry, medicinal chemistry, biological assay, and compound repository. My research involves chemistry, pharmacy and informatics. Since the last century, I have been developing algorithms for chemoinformatics / bioinformatics and pharmaceutical innovations, such as GMA (chemical database search engine, 1980s) CPA (fuzzy graph algorithm for protein structure determination from multi-dimensional NMR, 1990s), SCA (clustering large compound libraries, 2000s) and DLI algorithm (drug-like index, 2000s); WEGA (3D molecular superimposing, 2010s) DSGA (de novo frequent substructures recognition, 2010s). With these methods, my team discovered drug leads against osteoporosis, aging, glioblastoma, nasopharyngeal carcinoma, and other metabolic diseases. The leads against osteoporosis and glioblastoma have entered in the later pre-clinic studies and transferred to industry. I have published more than a hundred papers in international peer-reviewed journals. I am the inventor of more than 20 patents.

Ayman Helmy Kamel Mohamed

Professor

Analytical Chemistry, Chemistry Department

Ain Shams University, Cairo

Cairo, Egypt

About Me

Ayman is a member of the Technical Committee for the establishment of regulations and educational programs within the committees of the Ministry of Higher Education to supervise and follow-up national projects for the establishment of universities and educational institutions and research in the Arab Republic of Egypt. 1. Head of the Central Laboratory for microanalysis, Faculty of Science, Ain shams University from Nov.2015 till now. 2. Head of organizing committee for the first international scientific conference of Faculty of Science- Ain Shams University” New Frontiers in Science”, Hurgada, Red Sea, Egypt October 24-27, 2017. 3. Head of organizing committee for the second international scientific conference of Faculty of Science-Ain Shams University” New Frontiers in Science”, Hurgada, Red Sea, Egypt October 24 – 27, 2018. 4. Member of the Graduate Studies Committee-Chemistry Department, Faculty of Science, Ain Shams University. 5. Head of petroleum chemistry program, Faculty of arts and Science, American University of Nigeria, Yola, Nigeria. 6. Chemistry program coordinator, College of Science, Qassim University. 7. Member of Accreditation committee, College of Science, Qassim University. 8. Head of Assessment & Academic Accreditation committee, Chemistry Department, College of Science, Qassim University. 9. Head of laboratories, Equipments & Services committee, Chemistry Department, College of Science, Qassim University. Head of Higher education & research committee, Chemistry Department, College of Science, Qassim University.

GIUSEPPE LANZA

Senior University Researcher

Department of General Surgery and Medical-Surgical Specialties. Professor of Applied Medical Sciences Technologies

University of Catania, Catania (Italy)

CATANIA (ITALY) , Italy

About Me

Giuseppe Lanza has Participated  at Several International, National & Local Conference :

  • THE ANNUAL MEETING (MARCH 2015) OF THE WORLD ASSOCIATION OF SLEEP MEDICINE (WASM) IN SEOUL (SOUTH KOREA)
  •  THE 9TH INTERNATIONAL CONGRESS ON VASCULAR DEMENTIA (ICVD) (OCTOBER 2015) IN LJUBLJANA (SLOVENIA) 
  •  THE INTERNATIONAL RLS STUDY GROUP (IRLSSG) AND EUROPEAN RLS STUDY GROUP (EU-RLSSG) RLS/WED SCIENCE SUMMIT (OCTOBER 2015) IN PACIFIC GROVE, CA – USA 

Author of Some Famous Book :

  • Bella R, Pennisi G, Cantone M, Palermo F, Pennisi M, Lanza G, Zappia M, Paolucci S. Clinical presentation and outcome of geriatric depression in subcortical ischemic vascular disease. 
  • Pennisi G, Ferri R, Lanza G, Cantone M, Pennisi M, Puglisi V, Malaguarnera G, Bella R. Transcranial magnetic stimulation in Alzheimer’s disease: a neurophysiological marker of cortical hyperexcitability.

Charles Larson

Professor

Department of Communication Sciences and Disorders

Northwestern University

United States

Biography

My primary area of interest is in neural mechanisms of voice control. I have worked on this general topic for over 40 years. My early work was done on nonhuman primates in which we attempted to learn which areas of the brain are involved in vocalization through the brain lesioning approach. I also worked with Erich Luschei studying neural mechanisms of jaw control, and in this work, I learned how to do single unit recordings from the brain in awake behaving animals. In this work we made important discoveries of the role of jaw muscle spindle afferent endings on jaw control (J. Neurophysiology; J Physiology (London)). Thereafter with my move to Northwestern University, I used the single unit recording methods to study neural function in the midbrain periaqueductal gray and nucleus ambiguous in monkeys as they were vocalizing. This work demonstrated that the midbrain periaqueductal gray played an important role in the coordination of laryngeal and respiratory muscles on vocal control (Brain Research, Experimental Brain Research and the Journal of Neurophysiology). In about 1995 I developed a technique to study neural control of the voice by perturbing voice auditory feedback. This work was based on the well-established technique of perturbation analysis that has been used in other motor systems. In this work, we measure voice fundamental frequency and voice amplitude changes during steady vowel vocalizations as well as during speech following perturbations in auditory feedback. This technique has been widely accepted and is now used by voice scientists around the world. Our most recent work has involved ERP recording in the voice perturbation technique, and this research has led us to insightful discoveries of brain function during human vocalization. Namely, we have determined that voice pitch perturbations presented at the onset of vocalization activate a system that is important for identification of one’s own voice. Perturbations presented after the onset of vocalization trigger mechanisms that are involved in correcting for errors in vocal production. I began working with Don Robin about six years ago, and through this collaboration we have been using neuroimaging techniques (fMRI and PET) along with transcranial magnetic stimulation to study the role of auditory feedback in voice control. This work has also led to important papers on structural equation modeling and dynamic causal modeling of the neural circuitry involved in the role of auditory feedback in voice control (Neuroimage, Neuropsychologia). Most recently, working with my post-doctoral fellow, Dr. Sona Patel, we developed a new technique for the study of volitional mechanisms of voice control based on perturbations in voice auditory feedback. This technique allows us to investigate neural correlates of feedforward mechanisms of voice control. Altogether, the voice perturbation studies, ERP recordings, fMRI neuroimaging and neural modeling are leading to a better understanding of the neural mechanisms involved in the role of auditory feedback and voice control. My background in the establishment of new techniques for the study of neural mechanisms of voice control places me in an ideal position to participate in the studies in this proposal.

Emmanuel Olu Megbelayin

Senior Lecturer

Department of Ophthalmology

University of Uyo

Nigeria

Biography

He is a versatile Ophthalmologist with over 44 published scholarly articles and obtained Ophthalmology Fellowships from National Postgraduate Medical College of Nigeria, Sankara Eye Hospital Academy of Ophthalmology, Chennai, India, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, and Aravind Eye Hospital, Pondicherry, India. Currently a Senior Lecturer and Consultant Ophthalmologist/Vitreo-retinal Surgeon to University of Uyo and University of Uyo Teaching Hospital respectively. A recipient of Commonwealth scholarship with several presentations in local and international Ophthalmology conferences.

Zhongren (David) Zhou

Associate Professor

University of Rochester Medical Center

United States

Biography

Dr. Zhongren (David) Zhou is currently working as Associate Professor in Division of Cytopathology and GI pathology University of Rochester Medical Center New York. He has done his Bachelor’s in medicine from North China University of Science and Technology, Tangshan, China. Dr. Zhongren (David) Zhou has received his PhD in Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China. He has worked in various scientific societies like Western New York Society of Pathologists, United States & Canadian Academy of Pathology, Chinese American Pathologists Association, American Society of Cytopathology, American Society of Cytopathology, College of American Pathologists, American Society for Clinical Pathologists and Society of Neuroscience. Dr. Zhongren (David) Zhou has published around 50 scientific articles. Dr. Zhongren (David) Zhou is editorial board of 4 journals and has many reviewed publications. Dr. Zhongren (David) Zhou research interests include early diagnosis of esophageal adenocarcinoma and precancerous lesions by cytology and genome sequencing methods.

Ramona Moles

Research Assistant

University of Kansas Medical Center

United States

Biography

Dr. Ramona Moles is currently working as Graduate Research Assistant at Department of Pathology, University of Kansas Medical Center (USA). She received her Bachelors in Biological Sciences from University of Bologna (Italy). Dr. Ramona Moles received her Ph.D. Graduate Student Research Assistant in the Center for Viral Oncology and PhD student in the Department of Pathology and Laboratory Medicine, University of Kansas Medical Center. Dr. Ramona Moles currently on the editorial board of Journal of Oncology and Hematology, Journal of Pathology & Microbiology, Annals of Carcinogenesis, Austin Oncology, SM Journal of Hematology & Multiple Myeloma. Dr. Ramona Moles has many reviewed publications. Dr. Ramona Moles research interests include Molecular Toxicology, Pathway Deregulation in Human, DNA repair alteration in ATL leukemia.

Azizollah Nezhadali

Professor

Analytical Chemistry

Payame Noore University(PNU), Mashhad

Mashhad, Iran

HEMANGA HAZARIKA

Researcher

Division of Pharmaceutical Technology

Defence Research Laboratory (DRL) DRDO, Ministery of Defense

Tezpur, India

Prof. Lallan Mishra

Professor

Chemistry

Banaras Hindu University

Varanasi, India

Nahla Ahmed Hassan Farag

Professor

Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy

Misr International University MIU Cairo

Cairo, Egypt

A. V. Raghu

Professor

Department of Chemistry

Jain Deemed-to-be University

India

Current Issue Volume 1, Issue 1

On the Importance of Metabolic Stability to Achieve High Oral Exposures for Cyclic Peptides


Amberlite IR-120H Catalyzed Synthesis of 1,3-Diphenylpyrazolechromenoquinolin-6-one Compounds and Their Biological Evaluation


Ethnopharmacology, Phytochemistry and Pharmacological Properties of Cortex Phellodendri Chinensis: A Comprehensive Review


Application and Pharmacological Properties of Chinese Herb Danggui: A System Review


Neuroprotective Effects, Biological Activities and Therapeutic Potential of Phytochemicals: A Comprehensive Review


Carvacrol: A Brief Analysis of Molecular Properties and Their Therapeutic Potential


Stability Indicating HPLC Method for the Simultaneous Estimation of Triamcinolone Acetonide and Benzyl Alcohol in Pure Form and Epirelefan® Vial


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