Combined Treatment of Noninfected Diabetes-Related Foot Ulcerations with Preconditioned Autologous Platelet-Rich Plasma with the MCT System to Enhance Exosomes Release and Phototherapy: A Case Report

Author Info

Alexandra Amesty

Corresponding Author

Alexandra Amesty
Rosy Martín - Estética Integral (Aesthetic, Regenerative and Anti-Aging Medicine Department), La Salud, Los Llanos de Aridane, Santa Cruz de Tenerife, Canarias, Spain

A B S T R A C T

Diabetes-related foot ulceration is a common complication in patients with uncontrolled diabetes mellitus and is associated with high mortality. This case report describes an 83-year-old woman with more than 20 years of type Ib diabetes, hypertension, and five noninfected skin lesions on the lower limbs of a one-year evolution. The patient had failed previous treatments. Our treatment protocol consisted of a topical treatment using preconditioned autologous platelet-rich plasma with photothermal biomodulation using the MCT System, combined with phototherapy. The patient underwent three treatment sessions, one per week and a cleaning session four days after each treatment. The protocol applied was intended to increase the exosome released by platelets. After the three treatment sessions, the ulcers had a favorable evolution, reducing depth, size, and pain and allowing for their manipulation. The treatment had no technical difficulties or adverse effects. The patient regained mobility, which could improve her quality of life. Due to the results obtained, it can be concluded that the combined use of the topical application of preconditioned platelet-rich plasma with photothermal biomodulation using the MCT system and phototherapy could be an innovative regenerative option without immunogenic potential and low risk of complications for treating noninfected diabetes-related foot ulceration.

Article Info

Article Type

Case Report

Publication history

Received: Mon 17, Feb 2025
Accepted: Thu 10, Apr 2025
Published: Mon 12, May 2025

Copyright

© 2023 Alexandra Amesty. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.IJRGM.2025.01.01