Axonal Transport in Coats’ Disease and Congenital Oculodentodigital Syndrome

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for researchers?

A: Very Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good

Comments: Keywords are missing

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

Comments: Introduction section is missing. Goal needs to be stated in the introduction section.

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Comments: Introduction/background section is missing.

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Very Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments:

The conclusion section discusses the study findings for Coat’s disease in the reported case. The findings for the two eyes from Case 2, which were used as controls for the Coats’ disease immunohistochemistry analysis, have also been interpreted in this section. The study concludes that although the ODDDS specimens from Case 2 were used as background staining non-glaucomatous controls, important findings from Case 2 were obtained. The findings present additional anomalies that may be observed in this rare disorder.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Very Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very Good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments:

This report presents axonal transport block in the lamina cribrosa of a two-year-old male with Coats’ disease in his right eye. He was enucleated prior to presentation. Additionally, two eyes from a 5-month-old female infant, diagnosed with congenital oculodentodigital syndrome at autopsy, were used as controls for immunohistochemistry analysis and to identify additional findings for Coats’ disease. Histopathology analysis of the enucleated Coats’ globe and two additional autopsy eyes from the ODDDS case was performed. In addition to typical pathology for Coats’ disease, marked orthograde axonal transport block in the lamina cribrosa was observed in the first case. The study concludes that the key new finding in this study is the clear evidence of lamina cribrosa block of orthograde axonal transport in pediatric glaucoma, thereby supporting previous study findings.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team