Discordance of HER2 Positive Classic Invasive Lobular Carcinoma Between IHC/FISH and Oncotype DX: A Case Report and Literature Review

Discordance of HER2 Positive Classic Invasive Lobular Carcinoma Between IHC/FISH and Oncotype DX: A Case Report and Literature Review

Review Data

Q: Is the topic relevant to the journal's area of interest? Is it contemporary and interesting for


A: Good


Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good



Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good



Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good


Tools and Methods

Q: Are the methods the author uses adequate and well used?

A: Good


Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good


Comments: The Discussion highlighted the HER2 positive rate of classical ILC (cILC). The authors compared the concordance of the IHC negative and IHC positive cases providing relevant literature review. The Discussion further described the reason behind the overall high concordance (>95%) between IHC/FISH and ODX for HER2 testing. Authors indicated that further prospective studies will help to understand the subtype of the breast cancer. The conclusion puts forth the examples of subtypes of breast cancer at several stages. Lastly, the author suggests that the clinical management should not only be based on the tumor markers status from Oncotype DX (ODX).



Q: Does the author utilize relevant literature?

A: Good


Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good



Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good


Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Good


Writing style

Q: Is it clear and understandable?

A: Good


Further comments on the paper

Comments: The manuscript presents a case of a 70-year-old woman with a medical history of screening mammogram that revealed an indeterminate asymmetry in her right breast. Later, with ultrasound-guided biopsy found the presence of invasive lobular carcinoma. The case report highlights the discordance of positive classic invasive lobular carcinoma between IHC/FISH and Oncotype DX (ODX).


Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team


Author Info

Corresponding Author
Khin Su Mon
Department of Pathology and Laboratory Medicine, Loyola University Medical Center, Maywood, Illinois, USA

Article Info

Article Type
Case Report and Review of the Literature
Publication history
Received: Wed 18, May 2022
Accepted: Thu 02, Jun 2022
Published: Tue 14, Jun 2022
© 2021 Khin Su Mon. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.SCR.2022.06.01