Discordance of HER2 Positive Classic Invasive Lobular Carcinoma Between IHC/FISH and Oncotype DX: A Case Report and Literature Review
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Abstract & Keywords
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Tools and Methods
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Discussion & Conclusion
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Comments: The Discussion highlighted the HER2 positive rate of classical ILC (cILC). The authors compared the concordance of the IHC negative and IHC positive cases providing relevant literature review. The Discussion further described the reason behind the overall high concordance (>95%) between IHC/FISH and ODX for HER2 testing. Authors indicated that further prospective studies will help to understand the subtype of the breast cancer. The conclusion puts forth the examples of subtypes of breast cancer at several stages. Lastly, the author suggests that the clinical management should not only be based on the tumor markers status from Oncotype DX (ODX).
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Further comments on the paper
Comments: The manuscript presents a case of a 70-year-old woman with a medical history of screening mammogram that revealed an indeterminate asymmetry in her right breast. Later, with ultrasound-guided biopsy found the presence of invasive lobular carcinoma. The case report highlights the discordance of positive classic invasive lobular carcinoma between IHC/FISH and Oncotype DX (ODX).
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A: Yes - Suitable to be published
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Corresponding AuthorKhin Su Mon
Department of Pathology and Laboratory Medicine, Loyola University Medical Center, Maywood, Illinois, USA
Article TypeCase Report and Review of the Literature
Publication historyReceived: Wed 18, May 2022
Accepted: Thu 02, Jun 2022
Published: Tue 14, Jun 2022
Copyright© 2021 Khin Su Mon. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.