A Comprehensive Expression Profile of tRNA-Derived Fragments in Papillary Thyroid Cancer

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for

researchers?

A: Good

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Good

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Good

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Good

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Good

Comments: The Discussion describes the composition and expression of tRNA derived fragments (tRFs) in patients with papillary thyroid cancer (PTC) and explains the process of sequencing and regulation pattern of tRFs. In addition, it also highlights the role of tRFs in cancer suppression citing relevant literature. It also discusses the limitations of this study and states that further clinical cohort analysis is required regarding how tRFs affect the occurrence and development of PTC by affecting biological metabolism.

Literature

Q: Does the author utilize relevant literature?

A: Good

Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Good

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Good

Writing style

Q: Is it clear and understandable?

A: Good

Further comments on the paper

Comments: The study provides a comprehensive expression profile of tRNA derived fragments (tRFs) of fresh frozen specimens of papillary thyroid cancer (PTC) tissues considering four postoperative PTC patients (1 woman, 3 men) with age range of 30-50 years using RNA sequencing. It also states that the preliminary findings of this study can be used as the basis for further research in the field of tRFs.

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Science Repository Team