Overexpression of SP6 Correlates with Osteosarcoma Metastasis and Poor Prognosis

Overexpression of SP6 Correlates with Osteosarcoma Metastasis and Poor Prognosis

Review Data

™      Significance of the Study: This study is significant in the light of the elusive molecular mechanism underlying osteosarcoma metastasis and prognosis. It shows high expression of Specificity Protein 6 (SP6) in metastatic osteosarcoma tissues indicating SP6 serving as an independent prognostic biomarker in osteosarcoma, since the search for prognostic biomarkers for cancer is a major challenge. A comparison between mRNA expression of SP6 between metastatic and non-metastatic osteosarcoma tissues has been presented well in this research. The relatively small sample size comes out as a limitation of this study.

 

™      Fit with Journal: The manuscript is highly suited for the Journal of Surgical Oncology.

 

™      The study undertaken is quite convincing and the observations are appropriately examined and clarified in the Discussion. The Results are consistent in identifying SP6 as a potential prognostic biomarker in osteosarcoma. The Conclusion is congruous with the evidences presented in the article. Further experimental validation, both in vitro and in vivo, would be required in future studies to identify the biological roles of SP6 in osteosarcoma.

 

™      The manuscript is well-written except a few minor errors (already corrected in the galley proof), which are listed below –

 

§  In the 3rd sentence of 2nd paragraph of Introduction, “a important” should be replaced with “an important”.

§  In the last sentence of “Statistical Analysis”, “of survival” should be replaced with “for survival”.

§  Comma should be introduced after “clinical data” in the 2nd sentence of “Data Mining” and comma should be removed from “microenvironment and activation” in the 2nd sentence of 3rd paragraph of Discussion.

Author Info

Corresponding Author
Dongmei Guo
Department of Hematology, Taian City Central Hospital, Taian, Shandong, People's Republic of China

Article Info

Article Type
Research Article
Publication history
Received: Tue 21, Jul 2020
Accepted: Tue 04, Aug 2020
Published: Wed 12, Aug 2020
Copyright
© 2023 Dongmei Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JSO.2020.04.06