Effect of Electrospinning Parameters on the Fiber Diameter and Morphology of PLGA Nanofibers

Effect of Electrospinning Parameters on the Fiber Diameter and Morphology of PLGA Nanofibers

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for researchers?

A: Good

 

Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good

 

Goal

Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Excellent

 

Structure

Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good

 

Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Good

 

Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Very good

 

Comments: The Discussion section, with the help of adequate relevant literature, determines the appropriate electrospinning parameters such as applied voltage, flow rate, spinneret-collector distance (S-C distance) and polymer solution concentration for preparation of poly lactic-co-glycolic acid (PLGA) fibrous membrane for guided tissue regeneration/guided bone regeneration (GTR/GBR) applications and analyses the effect of the parameters on the mean fiber diameter of the electrospun PLGA nanofibers. The Conclusion states that there is a significant variation in the mean fiber diameter with altering solution concentration and the electrospinning parameters such as applied voltage, polymer solution flow rate and S-C distance, thus rejecting the null hypothesis. It also identifies the appropriate measures of the parameters for the production of PLGA nanofibers to be used in the GTR/GBR membrane fabrication.

 

Literature

Q: Does the author utilize relevant literature?

A: Very good

 

Author's knowledge

Q: What is the level of author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good

 

Length

Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good

 

Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Excellent

 

Writing style

Q: Is it clear and understandable?

A: Very good

 

Further comments on the paper

Comments: This study evaluates the effect of electrospinning parameters and polymer solution concentration on the mean fiber diameter of the electrospun poly lactic-co-glycolic acid (PLGA) nanofibers and determines the appropriate electrospinning parameters such as applied voltage, flow rate, spinneret-collector distance (S-C distance) and polymer solution concentration for the production of PLGA nanofibers to be used in the guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane fabrication. PLGA is a FDA-approved synthetic biodegradable polymer which has an excellent potential in a wide range of biomedical applications due to its unique properties. The findings of this study indicate that there is a significant variation in the mean fiber diameter with altering applied voltage, solution concentration, flow rate and S-C distance and thus, rejecting the null hypothesis. Thus, this study identifies the appropriate measures of the parameters and demonstrates that electrospinning parameters and solution concentration have a significant influence on the mean fiber diameter of electrospun PLGA nanofibers. Further studies are required to correlate the effect of mechanical properties and physical properties with mean fiber diameters and to determine the applicability of these nanofibers in various biomedical applications.

 

Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

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Author Info

Corresponding Author
Yuanyuan Duan
Associate Professor, Department of Biomedical Materials Science, University of Mississippi Medical Center, Jackson, Mississippi, USA

Article Info

Article Type
Research Article
Publication history
Received: Mon 26, Apr 2021
Accepted: Mon 10, May 2021
Published: Thu 20, May 2021
Copyright
© 2021 Yuanyuan Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository. All rights reserved.
DOI: 10.31487/j.DOBCR.2021.02.04