Hypotensive Effect Induced by Mandibular Extension in Aged, Hypertensive Humans and Rats

Hypotensive Effect Induced by Mandibular Extension in Aged, Hypertensive Humans and Rats

Review Data

Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for researchers?

A: Very good


Abstract & Keywords

Q: Are all required components included in the abstract? Are the keywords appropriately chosen?

A: Very good



Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?

A: Very good



Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?

A: Very good


Tools and Methods

Q: Are methods the author uses adequate and well used?

A: Excellent


Discussion & Conclusion

Q: Is it related to the results presented before? Do you consider them as coherent?

A: Excellent


Comments: The Discussion section, with the help of adequate relevant literature, demonstrates that submaximal mouth opening by mandibular extension (ME) induces a prolonged reduction in blood pressure, particularly in systolic pressure, not only in normotensive but even more in hypertensive subjects. In Conclusion, this study states that passive ME may be used as non-pharmacological aid in the treatment of moderate to mild arterial hypertension.



Q: Does the author utilize relevant literature?

A: Very good


Author's knowledge

Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?

A: Very good



Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?

A: Good


Figures & Tables

Q: Does the author use them suitably? Are legend and notations clear?

A: Very good


Writing style

Q: Is it clear and understandable?

A: Good


Further comments on the paper

Comments: This study provides the first evidence that mandibular extension (ME) has a significant role in inducing hypotensive effect when applied to rat and human subjects with high blood pressure, making their arterial blood pressure decrease toward normal values for at least two hours. It states that a passive sub-maximal opening of the mouth causes a significant reduction in arterial blood pressure. The findings suggest a relation between baseline blood pressure and hypotensive response so that the effects of ME appear greater in the hypertensive condition. This study is limited due to small sample size.


Q: Would you recommend this manuscript for further publication?

A: Yes - Suitable to be published

If you have any questions and clarifications you can write to the journal.

Science Repository Team


Author Info

Corresponding Author
Cristina Del Seppia
Institute of Clinical Physiology, National Council of Research (CNR), Pisa, Italy

Article Info

Article Type
Research Article
Publication history
Received: Mon 01, Mar 2021
Accepted: Tue 16, Mar 2021
Published: Mon 19, Apr 2021
© 2021 Cristina Del Seppia. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository. All rights reserved.
DOI: 10.31487/j.DOBCR.2021.01.06