The Value of Radiation Therapy for the Treatment of Diffuse Large B-Cell Lymphoma in a New Era
Q: Is the topic relevant to the journal area of interest? Is it contemporary and interesting for
A: Very Good
Abstract & Keywords
Q: Are all required components included in the abstract? Are the keywords appropriately chosen?
Q: Is the goal explicitly stated in the Introduction? Is its formulation clear and unambiguous?
A: Very Good
Q: Is the paper's structure coherent? Is it in coherence with the goal of the paper?
Comments: Heading ‘Conclusion’ is appropriate instead of ‘Summary’ at the end to better understand the findings in brief.
Tools and Methods
Q: Are methods the author uses adequate and well used?
Discussion & Conclusion
Q: Is it related to the results presented before? Do you consider them as coherent?
Comments: The review brings forth the importance of modern imaging and conformal radiation therapy (RT) for accurate tumor targeting. The authors suggest that RT should remain a standard practice and the benefit of RT in patients should be carefully understood. Lastly, the authors propose to perform more retrospective studies to figure out the correct value of RT.
Q: Does the author utilize relevant literature?
Q: What is the level of the author’s knowledge? Does the author utilize all recent contributions relevant to the topic?
Q: Is the length of the paper adequate to the significance of the topic? Do you suggest shortening the paper without losing its value?
Figures & Tables
Q: Does the author use them suitably? Are legend and notations clear?
Q: Is it clear and understandable?
Comments: There are a few errors found in the manuscript, which are as follows:
· In Abstract, 3rd sentence “Over the past few decades, … technology revolutions” must be written as “Over the past few decades, … technological revolutions”.
· Under Radiation Sources, 5th sentence, “Proton allows escalation of target tumor, …which potentially improving local control …” should be written as “Proton allows escalation of target tumor, … which potentially improves local control …”.
· Under Radiation Delivery, 4th paragraph, 2nd sentence, “It has an unique on board imaging capability … ability of taking the small errors…” should be “It has a unique on-board imaging capability … ability to take the small errors…”.
· Below heading Potential toxicities from radiation, 4th paragraph, “RT-induced toxicities were mild … limited to grade 1-3, which made the complete of scheduled radiotherapy without interruption possible” must be reframed as “RT-induced toxicities were mild … limited to grades 1-3, which made the completion of scheduled radiotherapy, without any possible interruption”.
· Under sub-heading, Relapsed/refractory disease, 3rd paragraph, last sentence, “Corresponding, the 2-year PFS rate was 88% and 27% respectively” must begin with “Correspondingly, the 2-year PFS rate was 88% and 27%, respectively”.
Further comments on the paper
Comments: The manuscript provides an understanding of the advancement in radiation technology for the treatment of diffuse large B-cell lymphoma (DLBCL) in modern days. The manuscript gives a clear overview of radiation sources, planning, and delivery. The authors illustrate the indications for the use of the radiation therapy among DLBCL patients having various disease outcomes. Further, it also highlights the potential toxicities of radiation therapy and to which extent its application should be limited.
Q: Would you recommend this manuscript for further publication?
A: Yes - Suitable to be published
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Corresponding AuthorBao-An Chen
Department of Hematology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province, China
Article TypeReview Article
Publication historyReceived: Wed 05, Jan 2022
Accepted: Thu 20, Jan 2022
Published: Mon 31, Jan 2022
Copyright© 2021 Bao-An Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.