Neutrophil to Lymphocyte Ratio in Lung Cancer: Implications for Depressive Symptoms and Survival

Neutrophil to Lymphocyte Ratio in Lung Cancer: Implications for Depressive Symptoms and Survival

Review Data

Purpose and Significance of Study: This is the first study to evaluate the use neutrophil to lymphocyte ratio (NLR) and its association with depression in patients with lung cancer. It was found that NLR provided a reasonable assessment of lung cancer related inflammation with survival implications that might indicate the presence of depression. The study is limited by its cross-sectional design, small sample size (109), and a single-institutional source of data.

 

Fit with Scope of Journal: The manuscript is of very high interest for the journal Clinical Oncology and Research.

 

Based on multiple pieces of research showing that depression is associated with inflammation, this study tested the hypothesis that neutrophil to NLR is elevated in depressed patients with lung cancer and that both elevated NRL and depression have prognostic implications. The discussion illuminated the importance of interpretation of the pro-inflammatory biomarker levels and inferred that NLR, while extensively studied as a prognostic marker, also added to the research on inflammation and depression, which was particularly relevant for patients with lung cancer who experienced high levels of anxiety and depression.

 

o   The manuscript contains some errors (already corrected in the galley proof, except the highlighted ones, which require the author’s attention) listed below –

 

·       Keywords are required, and out of the 3 tables provided, only table 1 is mentioned in the text.

·       In the 5th sentence of the 2nd paragraph of the Introduction, “C-reactant protein” must be replaced with “C-reactive protein”.

·       In the 2nd sentence of Distress in the Measures under Methods and Materials, “It is a one item measure of distress” must be removed as it is already mentioned in the previous sentence.

Author Info

Corresponding Author
Daniel McFarland
Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, USA

Article Info

Article Type
Research Article
Publication history
Received: Fri 22, May 2020
Accepted: Wed 10, Jun 2020
Published: Fri 19, Jun 2020
Copyright
© 2023 Daniel McFarland. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.06.12