Role of Wnt Signaling Pathways in Clear Cell Renal Cell Carcinoma Pathogenesis in Relation to VHL and HIF Status

Review Data

Purpose and Significance of Study: This is a review of the existing literature on the role of Wnt/ β-catenin signalling pathways and its crosstalk with VHL/HIF in clear cell renal cell carcinoma. 

 

Fit with Scope of Journal: The manuscript is of very high interest for the journal Clinical Oncology and Research. 

 

o   The manuscript is well-written and mostly error-free. A few minor errors (already corrected in the galley proof) are listed below –  

In the Introduction – 

  In the 1^st paragraph – 

·       In the 3^rd sentence, “5y” must be replaced with “5-year” twice, “,” must be inserted after “60%”, and “non-ccRCC types” before “constitute” must be removed as it is a repetition. 

·       In the 8^th sentence, “factor” before “(IGF)” is missing. 

In Role of Wnt co-factors in ccRCC – 

  In the 3^rd paragraph – 

·       In the 1^st sentence, “also” must be removed and inserted after “can”, and “factor” must be replaced with “factors”. 

In the Summary – 

·       In the 1^st sentence, “the” must be inserted before “development”. 

·       In the last sentence, “,” must be removed after “pathways”. 

Author Info

Börje Ljungberg Göran Roos Marene Landström Raviprakash T. Sitaram

Corresponding Author

Raviprakash T. Sitaram
Department of Medical Biosciences, Pathology, Translation Research Center (TRC), Umeå University, SE-901 85 Umeå, Sweden

Article Info

Article Type

Review Article

Publication history

Received: Mon 16, Mar 2020
Accepted: Thu 02, Apr 2020
Published: Fri 10, Apr 2020

Copyright

© 2023 Raviprakash T. Sitaram. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.03.09