Hsp70-2 is Highly Expressed in Nasopharyngeal Carcinoma and Involved in Nasopharyngeal Carcinoma Invasiveness

Review Data

Purpose and Significance of Study: This is a detailed study of the involvement of HSP70 in the metastasis of nasopharyngeal carcinoma, and the underlying mechanism.  

 

Fit with Scope of Journal: The manuscript is of very high interest for the journal Clinical Oncology and Research. 

 

o   The manuscript has a few minor errors (already corrected in the galley proof, except the highlighted ones which require the author’s attention), listed below – 

In the Title – 

·       “in” must be inserted after “expressed”. 

In the Abstract – 

·       In the 1^st sentence, “high metastasis characteristic” must be replaced with “highly metastatic character”. 

·       In the 5^th sentence, “dependent manner” must be replaced with “dependence” both times. 

In the Introduction – 

  In the 1^st paragraph – 

·       In the 3^rd sentence, “causing” and “led” must be replaced with “causes” and “lead” respectively. 

·       In the 7^th sentence, “high metastasis mechanism” must be replaced with “mechanism underlying the high metastasis”. 

  In the 2^nd paragraph – 

·       In the last sentence, “had” before “detected” must be removed and “metastasis” must be replaced with “metastatic”. 

In Materials and Methods – 

  Under Western-blotting assay – 

·       The heading must be changed to “Western blot”. The same goes for the words in the 1^st sentence. 

  Under ATPase Activity Assay – 

·       In the 1^st sentence, “added 200ul lysis buffer” must be replaced with “200 ul lysis buffer added”. 

·       The meaning of the last sentence “the supernatant…determined” is unclear, hence it must be re-written. 

  Under Immunohistochemical analysis – 

·       In the last sentence, “summed” must be replaced with “sum”. 

In Results – 

  Under DNP increases HSP70-2 expression and ATPase activity – 

·       In the 1^st sentence, “high expression” must be replaced with “highly expressed”. 

·       In the 9^th sentence, “ability” must be replaced with “activity”. 

·       In the 11^th sentence, “effect” must be replaced with “dependence”. 

In Discussion – 

  In the 1^st paragraph – 

·       In the 2^nd sentence, “NPC total metastasis rate” must be replaced with “the total metastasis rate for NPC”. 

·       In the 3^rd sentence, “were” must be replaced with “are”. 

·       In the 4^th sentence, “recurrent” must be removed. 

·       In the 7^th sentence, “to modify” and “to find” must be replaced with “modification of” and “finding” respectively, and “one of the” must be removed. 

  In the 2^nd paragraph – 

·       In the 4^th sentence, “chemical carcinogens in the carcinogenic process of NPC” must be removed. 

·       In the 5^th sentence, “have induced” must be replaced with “having induced”, and “nitrosamine” must be in plural; also, there is no such term as “nitroso moverin”, so it must be replaced. 

·       The 9^th sentence, “to further…protein” must be removed as it is unnecessary. 

Author Info

Faqing Tang Guizhi Tang Guodong Chen Jianhua Xiao

Corresponding Author

Faqing Tang
Department of Clinical Laboratory, The Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, Hunan, P.R. China

Article Info

Article Type

Research Article

Publication history

Received: Mon 24, Feb 2020
Accepted: Wed 25, Mar 2020
Published: Mon 30, Mar 2020

Copyright

© 2023 Faqing Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.03.02