Jasser Maatougui,Mehdi Raboudi,Tarek Taktak,Issam Msakni, Ramzi Khiari,Samir Ghozzi, Malignant Mesothelioma of the Epididymis: A Case Report of a Rare Paratesticular Neoplasm and Literature Review Surgical Case Reports 2020 2613-5965 http://dx.doi.org/10.31487/j.SCR.2020.12.16 https://www.sciencerepository.org/malignant-mesothelioma-of-the-epididymis-a-case-report-of_SCR-2020-12-116 Abstract: Background: Malignant mesothelioma of the epididymis is an extremely rare neoplasm with a poor prognosis and high potential of recurrence. Case Presentation: We report a case of a 28-year-old male with a left painless epididymal nodule. Scrotal ultrasound revealed a nodular mass with mixed echogenicity and Doppler showed increased vascularity. Radical orchidectomy was performed. Histopathological examination concluded to a malignant mesothelioma involving the epididymis. Metastatic workup was negative. The patient has undergone a regular follow-up and has been disease-free within 6 months. Conclusion: Malignant mesothelium of the epididymis is a diagnosis challenge. Surgery remains the main treatment. A multidisciplinary management should be offered in those cases. Keywords: Tumor, malignant, paratesticular, testis