Arezou Abbasi,Florencia G Jalikis ,Lisa K Koch ,Venu G Pillarisetty , Epidermoid Cyst within an Intrapancreatic Accessory Spleen Mimicking a Pancreatic Cystic Neoplasm Surgical Case Reports 2020 2613-5965 http://dx.doi.org/10.31487/j.SCR.2020.01.07 https://www.sciencerepository.org/epidermoid-cyst-within-an-intrapancreatic-accessory-spleen_SCR-2020-1-107 Abstract: Although intra-abdominal accessory spleens are commonly found in 10-30% of the general population, epidermoid cyst within an intrapancreatic accessory spleen (ECIPAS) is an extremely rare entity and is often misdiagnosed preoperatively as a cystic malignancy. We present the case of a 51-year-old man who was referred to our clinic because of an incidentally found pancreatic tail cystic mass. Due to CA 19-9 level over 2000 and high suspicion of malignancy, the patient underwent distal pancreatectomy with splenectomy. Histopathological analysis revealed a squamous epithelial lining with splenic parenchyma within the cyst wall, which was consistent with ECIPAS. The patient was discharged on postoperative day 4 without any complication. As this disease may mimic malignancy with no characteristic features in preoperative imaging, it should be considered in the differential diagnosis of pancreatic cystic lesions.Keywords: Intrapancreatic accessory spleen, epidermoid cyst, pancreatic cyst