Akiyo  Yoshimura,Ayumi  Kataoka,Haruru  Kotani,Hiroji  Iwata,Junko  Ishigro,Kayoko  Sugino,Madoka  Iwase,Masataka  Sawaki,Masaya  Hattori,Naomi  Gondo,Sakura  Ohnishi,
Vaccination-induced inflammatory accumulation of axillary lymph nodes detected by FDG-PET in a breast cancer patient
Surgical Case Reports
2018
2613-5965
http://dx.doi.org/10.31487/j.SCR.2018.03.006
https://www.sciencerepository.org/vaccination-induced-inflammatory-accumulation-of-axillary-lymph-nodes-detected-by-FDG-PET-in-a-breast-cancer-patient_SCR-3-106 
Abstract: Evaluation of axilla lymph node metastasis is very important in determining the treatment strategy for
primary breast cancer. The imaging method 2-fluoro-2-deoxy-D-glucose positron emission tomography
(FDG-PET) provides reliable information about metastasis, however it has limitations. A 40-year-old female
first noticed a mass in her left breast. Ultrasonography (US) showed an uncircumscribed mass measuring
1.5 cm beneath the nipple in her left breast, and swelling axilla lymph node as metastasis. Primary tumor
and 4 axilla lymph nodes were detected as hot spot by FDG-PET. However, we got new information which
she received influenza vaccination 4 days before she had undergone FDG-PET before determining the
strategy with patient. To decide the plan of treatment, it was necessary to have the reliable imaging result,
therefore, we performed the second FDG-PET 25 days after the influenza vaccination. We report a case
showing false-positive of axillary lymph nodes by FDG-PET caused by influenza vaccination. Influenza
vaccination before FDG-PET examination may cause axillary lymph node accumulations, especially within
several days after vaccination.Keywords: Breast cancer, FDG-PET, axilla lymph node, influenza vaccination, false-positive