Adel M. Abdel-Hakem,El-Shimaa M. N. Abdelhafez,Salsabel M. N. A. Ali,Sara Mohamed Naguib Abdelhafez,
Current Approaches in Dental Alveolar Abscess in Sight of Bone Related Drugs
Oral Rehabilitation and Dentistry
2019
2733-2543
http://dx.doi.org/10.31487/j.ORD.2019.01.05
https://www.sciencerepository.org/current-approaches-in-dental-alveolar-abscess_ORD-2019-1-105 
Abstract: Dentoalveolar abscess, a localized accumulation of pus in the alveolar bone, can produce significant changes
in alveolar bone proper that may be resulted by dental caries, trauma or pulpitis causing alveolar bone
resorption or even loss. Unfortunately, it can extend vertically toward the apex of the tooth. Additionally,
a periapical abscess may form in the alveolar bone adjacent to the apex of the tooth. Interestingly, many
bacterial products can stimulate osteoclast formation and bone resorption of periapical tissues. This review
displayed drugs that can affect bone resorption that classified as (1) Osteoclast inhibitors such as:
bisphosphonates, gene therapeutic (Cathepsin K) estrogens, selective estrogen receptor modulators
(SERMs), calcitonin monoclonal antibodies such as denosumab and (2) Osteoclast activators such as DMPPYT, nuclear factor-Kappa B (RANK) signaling and adrenomedullin.
Keywords: Abscess, Osteoclast, osteoblast, bone resorption, drugs