Alexandre Sacchetti Bezerra,Flavia Altheman Loureiro,Carla Maria Pasquareli Vazquez,Afonso Cesar Polimanti,Rafi Felicio Bauab Dauar,
Empiric Treatment of Foot Infection in Patients with Severe Diabetes
Journal of Integrative Cardiology Open Access
2021
2674-2489
http://dx.doi.org/10.31487/j.JICOA.2021.04.04
https://www.sciencerepository.org/empiric-treatment-of-foot_JICOA-2021-4-104 
Abstract: Background: Despite being treated with antibiotics of broad spectrum recommended by International Consensus, severe diabetic patients with lower limb infection do not present a positive clinical evolution during empirical treatment. This study’s bacterial profile was analysed and compared with other worldwide hospital centers. 
Objective: To confirm the need of an individualized empirical treatment for severe diabetic patients with foot infection. 
Methods: Retrospective analysis of cultures and antibiograms of severe diabetic patients admitted by foot infection. 
Results: The results were consistent with the socioeconomic realities of developing countries. Gram-negative bacteria (52,11%) were present in most bone cultures. Results presented a high incidence of Enterococcus faecalis in both gram-positive (21,2%) and polymicrobial (34,7%) samples. Bacterial resistance with the use of ordinary antibiotics in the statistical analysis was high. 
Conclusion: The community infections should undergo broad spectrum empirical therapy combining amikacin (80,43%) or meropenem (72,00%) with gram-negative and vancomycin (100%) or teicoplanin (90,00%) or linezolid (74,19%) with gram-positive.Keywords: Foot infection, diabetes, diabetic patients, cultures, antibiotics