Gang  Cheng,Mahesh  Krishnamurthy,
Psoriasis as the single risk factor for “Locked-in syndrome” after
ischemic stroke in a young patient: Case Report and Literature Review
Journal of Integrative Cardiology Open Access
2019
2674-2489
http://dx.doi.org/10.31487/j.JICOA.2019.01.002
https://www.sciencerepository.org/psoriasis-as-the-single-risk-factor-for-locked-in-syndrome-after-ischemic-stroke-in-a-young-patient_JICOA-2019-1-102 
Abstract: Background: Locked-in syndrome (LIS), also known as cerebromedullospinal disconnection or
pseudocoma, is a rare neurological disorder. LIS is most commonly caused by ischemic or hemorrhagic
pontine stroke. Autoimmune diseases have been shown to increase risk of cardiovascular disease and
cerebrovascular disease. Psoriasis as an isolated risk factor for LIS has not been described in literature
Case Description: A 50-year-old male patient with psoriasis and no other obvious risk factors presented to
the ER after being found in his home with loss of consciousness. He was diagnosed with basilar artery
thrombosis and pontine stroke which lead to post-stroke LIS.
Conclusion: Most patients seek treatment for psoriasis from a cosmetic perspective. It is important to stress
the cardiovascular and cerebrovascular risks associated with untreated psoriasis to patients who refuse
treatment. Our patient with locked-in syndrome makes this teaching point emphatically.Keywords: Psoriasis , ischemic stroke