Dan Wang,Dunjia Wang,Heng Lyu,Hengyi Du,Lian Cai,
Synthesis and Antimicrobial Activities of Containing Sulfur Heterocyclic Curcumin Derivatives
Journal of Biology Engineering and Medicine
2019

http://dx.doi.org/10.31487/j.JBEM.2019.01.04
https://www.sciencerepository.org/synthesis-and-antimicrobial-activities-of-containing-sulfur-heterocyclic_JBEM-2019-1-104 
Abstract: Eight novel containing sulfur heterocyclic curcumins were synthesized and characterized by 1H-NMR, FTIR and MS spectroscopy. Their antimicrobial activities against Staphylococcus aureus, Bacillus subtilis,
Escherichia coli and Aspergillus niger were also tested for MIC by using serial tube dilution method. The
results showed that the antimicrobial activities of synthesized curcumin derivatives were better than
curcumin. Especially, the compound 4-(1,3-dithiolan-2-ylidene)-1,7-di(thiophen-2-yl) hepta-1,6-diene-3,5-
dione (2g) exhibited excellent the antimicrobial activities among these curcumin derivatives.Keywords: Curcumins, sulfur heterocycle, synthesis, antimicrobial activity