Costa  Karihaloo,Maria Julia Corbetta Machado,
Cholecystectomy for Resistant Metastatic Malignant Melanoma of the Gallbladder: A Case Report
International Journal of Surgical Case Reports
2020
2674-4171
http://dx.doi.org/10.31487/j.IJSCR.2020.01.03
https://www.sciencerepository.org/cholecystectomy-for-resistant-metastatic-malignant-melanoma_IJSCR-2020-1-103 
Abstract: Malignant melanoma is an unpredictable disease, known to metastasize early even in thin melanomas.
Historically the presence of intraabdominal metastasis meant poor prognosis with a 5-year survival of less
than 20%. That has significantly changed with effective systemic therapy (EST), with most recent studies
reporting 5-year survival of up to 50%. Metastasecectomy for resistant disease has been considered in Stage
IV disease, however there is very little literature on the combination of EST and metastasectomy. This report
describes a case of Stage IV malignant melanoma patient who developed resistant disease within her
gallbladder fundic wall. She underwent open cholecystectomy, with complete metabolic response at 1-year
follow up PET.Keywords: Metastatic melanoma, gallbladder metastasis, gallbladder cancer