Fengxiang  Han,Caiwei  Lu,Chunxiang  Luo,Xiaohui  Liao,Donghua  Xie,Danni  XU,Yanda  LU,
Co-Occurrence of Multiple Sclerosis & Ovarian Cancer: A Case Report and Literature Review
Global Surgery Case Reports
2020
2733-2535
http://dx.doi.org/10.31487/j.GSCR.2020.02.14
https://www.sciencerepository.org/co-occurrence-of-multiple-sclerosis-and-ovarian-cancer-a-case_GSCR-2020-2-114 
Abstract: Background: The possibility of an association between Multiple Sclerosis (MS) and cancer has not been
thoroughly investigated.
Case Presentation: We present a case of ovarian cancer in 58-year-old woman with MS. Radical
hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and pelvic and para-aortic lymph node
dissection was performed. Pathohistological analysis and immunohistochemistry confirmed the diagnosis
of a clear cell carcinoma of the left ovary, grade Ⅲ, FIGO2014 stage IA. Adjuvant chemotherapy of
paclitaxel-carboplatin regimen (paclitaxel 175mg/m2, carboplatin AUC 6, at intervals of 3 weeks) was
implemented for 4 courses.
Conclusion: The occurrence of ovarian cancer in MS patients may be coincidental. Nevertheless, the longterm use of immunosuppressive and/or immunomodulatory drugs in MS and the incidence of cancer may
be associated.Keywords: Multiple sclerosis, ovarian cancer, incidence, risk factors, case report