Douglas Vieira Thomaz, How Phytocomponents May be Valuable Against Oxidative Stress in Brain Tissue? Global Drugs and Therapeutics 2020 2733-256X http://dx.doi.org/10.31487/j.GDT.2020.01.04 https://www.sciencerepository.org/how-phytocomponents-may-be-valuable_GDT-2020-1-104 Abstract: This short commentary is intended to briefly discuss the benefits of plant secondary metabolites against brain tissue injury promoted by oxidative stress. Henceforth, the physicochemical features and biological activities of phytocomponents were assessed based on literature reports, which showcased their thermodynamic feasibility to reduce reactive oxygen species. It was strongly hinted that secondary metabolites possessing antioxidant potential may be of use in the therapeutics against neurodegenerative disorders owing to free radical scavenging, what hinders further damage to brain tissue.Keywords: Antioxidants, polyphenols, brain tissue injury, herbal, folk medicine