Amr A. Mattar ,Mahmoud Mohammed Mohammed Sebaay,
Isoabsorptive Point Method for Simultaneous Determination of Paracetamol and Orphenadrine Citrate in Their Combined Pharmaceutical Dosage Forms
Global Drugs and Therapeutics
2020
2733-256X
http://dx.doi.org/10.31487/j.GDT.2020.01.01
https://www.sciencerepository.org/isoabsorptive-point-method-for-simultaneous-determination-of-paracetamol_GDT-2020-1-101 
Abstract: A simple, specific, accurate and precise spectrophotometric method was settled for simultaneous
determination of paracetamol and orphenadrine citrate in their pure form and in their pharmaceutical
formulation. Isoabsorptive point technique has been used in simultaneous determination of both drugs
without prior separation. Isoabsorptive point method parameters were validated according to ICH guidelines
in which accuracy, precision, repeatability and robustness were found in accepted limits. Advantages and
disadvantages of Isoabsorptive point were discussed and statistical comparison between the proposed
method and the reference one was also performed.Keywords: Spectrophotometric, Paracetamol, Orphenadrine, isoabsorptive point, ICH guidelines