Akhlaq  Ahmad,Ailin  Tao,Mushtaq  Ahmed,Nadia  Mushtaq,Ayesha Ali  Khan,Qing-Xin  Li,Muhammad Wasim  Jan Khan,
New Advances in Classical Wnt/β-Catenin Signaling in Cancer
Clinical Oncology and Research
2020
2613-4942
http://dx.doi.org/10.31487/j.COR.2020.09.06
https://www.sciencerepository.org/new-advances-in-classical-wntb-catenin-signaling-in-cancer_COR-2020-9-106 
Abstract: Wnt/β-catenin-mediated signaling is a key pathway regulating tissue growth and development and
tumorigenesis. This signaling pathway has received much attention in recent years. In addition to
participating in healthy tissue and organ development, inappropriate activation of this pathway can cause a
variety of tumors and other pathologies. It also plays a critical role in many processes such as proliferation,
differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition and dry maintenance of
human tumor cells. This review introduces the underlying mechanism of Wnt signaling pathway and
highlights the most recent research progresses on the relationship between Wnt signaling pathway and
tumor. Furthermore, the intrinsic link of Wnt signaling pathway to cancer stem cells is also discussed,
aiming to curb the malignant progression of tumors from the root cause. Finally, possible clinical strategies
harnessing the classical Wnt signaling pathway as a therapeutic target are summarized.Keywords: Wnt/β-catenin signaling, tumor, cancer stem cell, target, therapeutic strategy