Börje Ljungberg,Göran  Roos,Marene  Landström,Raviprakash  T. Sitaram,
Role of Wnt Signaling Pathways in Clear Cell Renal Cell Carcinoma Pathogenesis in Relation to VHL and HIF Status
Clinical Oncology and Research
2020
2613-4942
http://dx.doi.org/10.31487/j.COR.2020.03.09
https://www.sciencerepository.org/role-of-wnt-signaling-pathways_COR-2020-3-109 
Abstract: Renal cell carcinoma (RCC) encompasses various tumor types characterized by a variety of genetic
abnormalities. The genetic changes, like mutations, deletions, and epigenetic alterations, can affect the
signaling components and signaling networks, causing the modification of tumor pathogenesis and
prognosis of RCC. The most prevalent RCC, clear cell RCC (ccRCC), is asymptomatic in the early stages,
refractory to chemotherapy and radiation therapy, and has a poorer prognosis compared with the papillary
and chromophobe ccRCC types. Loss of the VHL gene and upregulation of oxygen sensors, hypoxiainducible factor alphas (HIF-α), which promote different growth factors, is a signature of sporadic ccRCC.
The VHL-HIF-α and Wnt/β-catenin pathways are closely connected and contribute to the ontogeny of
ccRCC. This review confines to ccRCC and the role of the Wnt/β-catenin signaling pathways and its
crosstalk with VHL/HIF.
Keywords: ccRCC, VHL/HIF, Wnt/β-catenin signaling pathway