Yi-Zarn Wang ,Brianne Voros ,David T. Beyer ,Eugene A. Woltering ,Ioni Kokodis ,Irma Oliva ,J. Philip Boudreaux ,M. Jennifer Ricks ,Ramcharan Thiagarajan ,Robert A. Ramirez,Yvette Bren Mattison, Liver Needle Biopsies are Poor Predictors of Histologic Tumor Grade for Midgut Neuroendocrine Tumors Clinical Oncology and Research 2020 2613-4942 http://dx.doi.org/10.31487/j.COR.2020.01.07 https://www.sciencerepository.org/liver-needle-biopsies-are-poor-predictors-of-histologic_COR-2020-1-107 Abstract: Background: Our group has previously shown than neuroendocrine tumors (NETs) are heterogeneous neoplasms having histologic and functional differences between their primary tumor, lymph node, and hepatic metastases. Due to the heterogeneity of these malignancies, we hypothesized that there would be discordance between the histologic grade of surgical specimens and that predicted by preoperative biopsies. Methods: Twenty consecutive patients diagnosed with NETs of the ileum and hepatic metastasis were included. Ki-67 proliferative index and WHO 2010 histologic grade were recorded for preoperative hepatic needle biopsy and subsequent tissue-matched surgical specimens. Concordance between sample values was determined. Results: Ten males and 10 females were included in this analysis. Five and 15 patients had fine-needle aspirate (FNA) and core needle biopsies, respectively. Preoperative biopsies predicted the histologic grade of subsequent tissue-matched surgical specimens in only 65% of samples (13/20). Of the 7 values that changed grade (7/20, 35%), 4 went from intermediate (G2) to low (G1) grade [1 FNA and 3 core biopsies] and 3 went from low (G1) to intermediate (G2) grade [1 FNA and 2 core biopsies]. The corresponding interrater agreement statistic (K) was 0.251±0.230 (95% CI: -0.199-0.702), with 0.21