CHEN Bao-An,GUO Nan-Nan,WU Yi-Ting,LIU Yan-Wen,Yi-Qian ZHU,
Relationship Between Single Nucleotide Polymorphisms and the Toxicy and Side Effects of Paclitaxel and Platinum-Based Chemotherapy in Patients with Malignant Tumors
Clinical Oncology and Research
2019
2613-4942
http://dx.doi.org/10.31487/j.COR.2019.05.06
https://www.sciencerepository.org/relationship-between-single-nucleotide-polymorphisms-and-the-toxicy-and-side-effects-of-paclitaxel-and-platinum-based-chemotherapy-in-patien_COR-2019-5-106 
Abstract: Objective: Investigating the relationship between single nucleotide polymorphisms (SNPs) and the toxic
and adverse effects of paclitaxel and platinum-based chemotherapy in patients with malignant tumors, to
provide recommendations for individualized treatment.
Methods: Determinate 17 patients with malignant tumor DNA site and analysis.
Results: 1. All 17 selected specimens’ fluorouracil related genes 18DPYD*2A(476002G>A)GG type、
153DPYD*13(1679T>G)TT type 154DPYD(2846A>T)TT type, and the synthesis of DPYD enzyme
activity. 21GSTP1(313A>G) polymorphism site mutation rate was 25.0%(4 cases),
29XRCC1(16323944T>C) polymorphism site mutation rate was 90.9%(10 cases), 62ABCB1(3435C>T)
polymorphism site mutation rate was 52.9%(9 cases), and 68MTHFR(677C>T) polymorphism site mutation
rate was 50.0%(8 cases). 2. Fluorouracil related genes 18DPYD*2A(476002G>A)GG type,
153DPYD*13(1679T>G)TT type, 154DPYD(2846A>T)TT type ,and the synthesis DPYD enzyme activity
is normal. 3. Paclitaxel related genes 62ABCB1(3435T>C) CC type has a lower incidence of
hematotoxicity and neurotoxicity, than CT type and TT type. 13ABCB1(2677T>G)GG type has a higher
rate of drug resistance than TT type. 14CYP1B1*3(C>G)CC type has a higher progression-free survival.
Platinum-related genes 21GSTP1(313A>G)AA is homozygous wild type and has a higher incidence of
hematotoxicity than GA type. 29XRCC1(1196T>C)CC is homozygous mutant and has a higher risk of
serious neutropenia than CT type. 62ABCB1 (3435T>C)CC is homozygous mutant and has a higher risk of
lymphatic metastasis than TC type and TT type. 68MTHFR(677C>T)TT type is homozygous mutant and
has a higher mucosal toxicity and toxic and side effects than CT type and CC type.
Conclusion: Single nucleotide polymorphism is related to the toxic and side effects of chemotherapy，the
detection of SNP to predict the toxicity risk of drug users can be an important reference index to guide
clinical individualized treatment.Keywords: Single nucleotide polymorphisms(SNPs), malignant tumor, paclitaxel, platinum, chemotherapy, toxic and side effect