Cristina  Zucchinetti,Edoardo  Benedetti,Elena  Ciabatti,Enrico  Orciuolo,Eugenio Mario  Ciancia,Federico  Rossari,Francesca  Guerrini,Francesco  Caracciolo,Gabriele  Buda,Luca  Biavati,Maria Immacolata  Ferreri,Mario Petrini,Sara Galimberti,Susanna  Grassi,Ugo  Boggi,
Role of Circulating DNA in the Precocious Diagnosis of Lymphoma: an example in a Transplant-Related Aggressive Lymphoma
Clinical Oncology and Research
2019
2613-4942
http://dx.doi.org/10.31487/j.COR.2019.02.02
https://www.sciencerepository.org/role-of-circulating-dna-in-the-precocious-diagnosis-of-lymphoma-an-example-in-a-transplant-related-aggressive-lymphoma_COR-2019-2-102 
Abstract: We report the case of an aggressive non-Hodgkin lymphoma transmission from a live renal donor to her
recipient. Soon after donation, the donor developed a high-grade B cell lymphoma, and the disease became
evident also in the recipient three months thereafter, showing the same biological characteristics as
confirmed by IgH rearrangement, karyotype and chimerism analyses. In the recipient, the IgH clone
appeared in circulating cell free DNA (cfDNA), but not in peripheral blood nor in bone marrow, one month
earlier than the imaging evidence of disease.
This case supports the fundamental predictive role of molecular analysis of the plasma compartment in the
diagnosis and putatively follow up of lymphomas
Keywords: Circulating DNA, high grade B-cell lymphoma, transplant-related lymphoma, donor cancer transmission, precocious biomarker