Daisuke  Sato,Junko Sugiyama,Masahiro Yoshida,Michiaki  Hirayama,Naoka  Okamura,Shuji  Kitashiro,Shunichi  Okushiba,Shutaro  Oiwa,Toshizo  Takayama,Yasushi Tsuji,
Metabolic complete response after docetaxel, cisplatin and S-1 (DCS) therapy and sequential radiation therapy in a patient with anal squamous cell carcinoma: a case report
Clinical Oncology and Research
2018
2613-4942
http://dx.doi.org/10.31487/j.COR.2018.10.011
https://www.sciencerepository.org/metabolic-complete-response-after-docetaxel-cisplatin-and-therapy-and-sequential-radiation-therapy-in-a-patient-with-anal-squamous-cell-carcinoma_COR-1-111 
Abstract: Chemoradiotherapy is the standard treatment for anal squamous cell carcinoma (SCC). Recently，it has
been reported that a combination therapy of taxane, platinum and fluoride pyrimidine is useful for SCC. A
58-year-old woman was admitted to our hospital with anal pain and constipation. Computed tomography
(CT) scan revealed a 9×6 cm tumor, stenosis in the anal region, and swollen pelvic and inguinal lymph
nodes. She underwent laparoscopic ileal stomatoplasty and biopsy. A diagnosis of SCC of anal canal was
confirmed by histopathological examination. She received a combination therapy with docetaxel, cisplatin
and S-1 (DCS), followed by radiation therapy (RT). After her chemoradiotherapy, no abnormal
accumulation was observed on a positron emission tomography-computed tomography (PET-CT) scan, and
she was diagnosed with metabolic complete response (CR). The 3-drug combination therapy of taxane,
platinum, fluoride pyrimidine followed by RT as primary treatment may be effective in the treatment of anal
SCC.Keywords: docetaxel, cisplatin , anal squamous