Ayse  Nur Akatlı,Cemil  Colak,Ebru Inci  Coskun,Ercan  Yilmaz,Nurhan Şahin,Nusret  Akpolat,Umran Karabulut  Dogan,
The Significance of p53 and Estrogen Expression in Endometrial Hyperplasias and Endometrioid Carcinomas
Clinical Oncology and Research
2018
2613-4942
http://dx.doi.org/10.31487/j.COR.2018.10.001
https://www.sciencerepository.org/the-significance-of-p53-and-estrogen-expression-in-endometrial-hyperplasias-and-endometrioid-carcinomas-COR_1-101 
Abstract: Objective: Endometrial carcinomas are the most commonly encountered malignancies of the female genital
system. The tumours are sub-classified into two types; type I, endometrioid carcinoma (EC) and type II,
serous carcinoma (SC). Accumulation of p53 protein have been detected in SC whereas they are not
common in endometrial hyperplasia and EC.
Materials-Methods: This study is a retrospective evaluation of 51 endometrioid carcinomas, 46
endometrial hyperplasias with/without atypia. In all three groups, the correlations between epithelial/
stromal p53 and estrogen expression (ER) and cervical, myometrial and lymphovascular invasion and
relationship tumour grades were determined.
Results: Significant differences were noted between hyperplasia with atypia and non-hyperplasic
endometria, epithelial p53 immunostaining (p<0.05). ER expression were stronger in hyperplasias
with/without atypia than EC in both epithelial and stromal components (p<0.05). The relationship between
tumour grade and p53 and ERs epithelial/ stromal expression was investigated however no statistically
significant correlation was found.
Conclusion: The present study found that, most EC cases have a higher p53 but lower ER expression. P53
expression can be used as an indicator of tumour aggressiveness. In addition to known factors that need to
be considered when evaluating endometrioid carcinomas and their precursor lesions, first glance importance
should be given to epithelial expression of p53 and stromal expression of ER.Keywords: Endometrial hyperplasia,  p53 expression,  estrogen expression,  Endometrioid carcinoma