Alejandro Sousa, SARS-Cov-2 Natural or Artificial? That is the Question Clinical Microbiology and Research 2020 2674-418X http://dx.doi.org/10.31487/j.CMR.2020.01.06 https://www.sciencerepository.org/sars-cov-2-natural-or-artificial-that-is-the-question_CMR-2020-1-106 Abstract: The COVID-19 pandemic has become the most serious health problem of the 21st century. Knowing whether its origin was natural or artificial is an extremely important fact, especially due to the ethical debate that should be generated on gain-of-function investigations in high-security laboratories around the world. We analyse all the existing evidence on the possible origin of the SARS-CoV-2 trying to join the pieces and thus obtain an overview that allows us to see beyond the isolated publications. Keywords: SARS-Cov-2, COVID-19, natural, artificial, origin, spike protein